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Literature summary extracted from

  • Grunewald, G.L.; Caldwell, T.M.; Li, Q.; Criscione, K.R.
    Synthesis and evaluation of 3-trifluoromethyl-7-substituted-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor (1999), J. Med. Chem., 42, 3315-3323.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.28 3-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline
-
 Bos taurus
2.1.1.28 3-trifluoromethyl-7-bromo-1,2,3,4-tetrahydroisoquinoline
-
 Bos taurus
2.1.1.28 3-trifluoromethyl-7-cyano-1,2,3,4-tetrahydroisoquinoline
-
 Bos taurus
2.1.1.28 3-trifluoromethyl-7-nitro-1,2,3,4-tetrahydroisoquinoline
-
 Bos taurus
2.1.1.28 7-methylsulfonyl-3-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline
-
 Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.28 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.28 adrenal gland
-
 Bos taurus
-

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.1.28 0.00052
-
 3-trifluoromethyl-7-bromo-1,2,3,4-tetrahydroisoquinoline
-
 Bos taurus
2.1.1.28 0.002
-
 3-trifluoromethyl-7-nitro-1,2,3,4-tetrahydroisoquinoline
-
 Bos taurus
2.1.1.28 0.013
-
 3-trifluoromethyl-7-cyano-1,2,3,4-tetrahydroisoquinoline
-
 Bos taurus
2.1.1.28 0.015
-
 3-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline
-
 Bos taurus
2.1.1.28 0.036
-
 7-methylsulfonyl-3-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline
-
 Bos taurus